Create an experiment
General DoE (Design of Experiment) Approach
| Goal | Procedure |
|---|---|
| Many unknown questions. Does it work basically? | → Make pre-studies |
| It works basically. Which factors need to be changed in order to perform better? | → Make screening experiments |
| I know which factors are important. But where is the optimum? | → Make optimization experiments |
Experiment Creation Workflow
- Determine the measurement technique for the response(s) (y1, y2, ..., yn)
- Definition of the factors (x1, x2, ..., xn)
- Define factor levels
- Screening designs → 2 levels
- Optimization designs → 3 levels
- Define the number of centerpoints
- Randomize the experimental plan
- Desice takes care of randomizing your experimental plan
- Finalize the experimental plan
- Check if extreme factor settings are realizable
Featured Experimental Plans
| Type | Designs |
|---|---|
| Screening Designs | Full-Factorial |
| Fractional-Factorial | |
| Plackett-Burman | |
| Optimization Designs | Box-Behnken |
| Central Composite | |
| CCF (Default, center-faced) | |
| CCC (Center-circumscribed) | |
| CCI (Center-inscribed) | |
| Mixture | Simplex Lattice |
| Simplex Centroid | |
| Optimal | D-Optimal |
| Bayesian Optimization | Random Strategy |
Creation Workflow Example
Let's say you are a process engineer working for a company in the R&D department. The scientists at your company have found a way for synthesizing the main product at low temperature and pressure. It basically works on a laboratory scale, and there was approval by management for a pilot-scale trial.
Your job is to set up an experimental plan to find out which factors need to be changed to increase yield and decrease the cost.
As an experienced engineer, you come up with the following factor settings. Additionally, you define three centerpoints.
Factor Settings
| Factor | Range |
|---|---|
| Temperature | 300 - 400 °K |
| Pressure | 1 - 2 bar |
| Concentration A | 150 - 300 mg/L |
| Concentration B | 200 - 300 mg/L |
Factor Settings in the Laboratory
| Factor | Value |
|---|---|
| Temperature | 350 °K |
| Pressure | 1.5 bar |
| Concentration A | 275 mg/L |
| Concentration B | 200 mg/L |
In the following video, the workflow for creating an experimental plan is shown.